PBHM Workshop: Silvin Knight

Silvin Knight, Senior Postdoc with the FRAILMatics research project, will lead this workshop titled "Frailty, Entropy, and the Brain". FRAILMatics overarching aim is to develop more accurate frailty tools that (without expert input) will automatically identify subtle dysregulated responses to stressors across physiological systems, using both population (N > 8500) and clinical (N ~100) cohorts. Silvin will present recent work from FRAILMatics and The Irish Longitudinal Study on Ageing (TILDA) on the quantification of neuro-cardiovascular dysregulation using signal entropy, and the associations of this novel measure with hard outcomes, such as frailty, cognitive performance, mortality, and biological brain age. He will also present current work investigating how frailty is related with brain structure and function.