PBHM Workshop: Rob Whelan

PBHM Investigator, Robert Whelan, will present “Predicting who will respond to stimulant medication in ADHD: A precision medicine approach using neurally informed computational models”. In this workshop, Rob will present the outline of a project that will start in March 2022. The goal of this project is use precision medicine to improve treatment of childhood Attention Deficit Hyperactivity Disorder (ADHD). Methylphenidate is the first-line pharmacological treatment but there is wide individual variation in outcomes: 30% of children will have no clinically meaningful response. There is currently no validated objective, quantitative method for predicting who will ultimately respond. Together with co-PI Jane McGrath, and industry collaborators, Cumulus Neuroscience, this project will use neurally informed computational models derived from behaviour and electroencephalography to decompose medication effects on distinct neural mechanisms in a large cohort of medication naive patients ages 10-14 years. Interrogating this immense amount of data will be solved by using…